The aim of this study was to assess the prevalence and associated factors of depressive symptoms and perceived stress among people with Type 2 diabetes mellitus (T2DM) in Nepal. Using a cross-sectional design, we collected data from 481 participants with T2DM in Kavrepalanchok and Nuwakot districts of Nepal. Depressive symptoms and perceived stress were assessed using Patient Health Questionnaire (PHQ-9) and Perceived Stress Scale, respectively. Associated independent variables were examined using binary logistic regression analyses. Of 481 participants, 123 (25.8%) had depressive symptoms (PHQ-9 score ≥5) and 156 (32.4%) experienced perceived stress. Low monthly income (