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Controlled stress improves oocyte performance : cell preconditioning in assisted reproduction

journal contribution
posted on 06.12.2017, 00:00 by C Pribenszky, L Lin, Y Du, E Losonczi, A Dinnyes, Gabor VajtaGabor Vajta
A recently emerged concept utilizing a controlled environmental impact as a treatment for cells and tissues aims to improve neither the in vitro conditions nor the procedures, but the cell itself. Hydrostatic pressure stress emerged as the most controllable and most effective stressor, proving the principle that controlled stress improves cell performance in in vitro procedures, whereas further studies using different stressors (osmotic, oxidative or mechanic stresses) supported the principle. The present summary reviews studies of various stress treatments to treat oocytes of three species (murine, porcine, human) before vitrification, in vitro maturation, enucleation and somatic cell nuclear transfer. Eventually, cleavage and blastocyst rates and – in cases when hydrostatic pressure was used – blastocyst cell number and birth rates as well were significantly improved compared to untreated controls.

Funding

Other

History

Volume

47

Issue

Suppl4

Start Page

197

End Page

206

Number of Pages

10

eISSN

1439-0531

ISSN

0936-6768

Location

Germany

Publisher

Wiley-Blackwell Verlag GmbH

Language

en-aus

Peer Reviewed

Yes

Open Access

No

Era Eligible

Yes

Journal

Reproduction in domestic animals.