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Comparison of mucosal and parenteral immunisation in two animal models of pneumococcal infection : otitis media and acute pneumonia

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journal contribution
posted on 06.12.2017, 00:00 by A Cripps, Jennelle KydJennelle Kyd
Bacterial clearance and immune responses in a mouse model of pneumonia and a rat model of otitis media following parenteral or mucosal immunisation in both models were compared. Both the immunisation routes were equally effective in inducing bacterial clearance from the lung, upregulated the recruitment of white cells and lead to an increase in the concentration of TNF-, IL-1 and specific antibody in the bronchoalveolar lavage. Both the routes of immunisation enhanced clearance of bacteria from the middle ear. Parenteral immunisation was most effective overall in enhancing bacterial clearance and recruiting white cells to the middle ear. Both the routes significantly suppressed the levels of TNF- in the middle ear lavage. Mucosal immunisation induced a Streptococcus pneumoniae-specific IgA antibody response. Both the animal models gave highly reproducible disease and provided high levels of sensitivity for testing the efficacy of candidate vaccine antigens. Differences observed in the inflammatory responses require further study.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

25

Issue

13

Start Page

2471

End Page

2477

Number of Pages

7

eISSN

1358-8745

ISSN

0264-410X

Location

United Kingdom

Publisher

Elsevier

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Chancellery; Griffith University;

Era Eligible

Yes

Journal

Vaccine.