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Circadian gene variants and breast cancer

journal contribution
posted on 04.07.2018, 00:00 by E Reszka, M Przybek, Olav Muurlink, B Pepłonska
The endogenous and self-sustained circadian rhythm generated and maintained in suprachiasmatic nucleus and peripheral tissues can coordinate various molecular, biochemical and physiological processes in living organisms resulting in the adaptation to environmental cues, e.g. light. Multifactorial breast cancer etiology also involves circadian gene alterations, especially among individuals exposed to light at night. Indeed, shift work that causes circadian disruption has been classified by the International Agency for Research on Cancer as a probable human carcinogen, group 2A. Thus it seems extremely important to recognize specific susceptible gene variants among around 20 candidate circadian genes that may be linked with breast cancer etiology. The aim of this review was to evaluate recent data investigating a putative link between circadian gene polymorphisms and breast cancer risk. We summarize fifteen epidemiological studies, including five studies on shift work that have indicated BMAL1, BMAL2, CLOCK, NPAS2, CRY1, CRY2, PER1, PER3 and TIMELESS as a candidate breast cancer risk variants.

Funding

Other

History

Volume

390

Start Page

137

End Page

145

Number of Pages

9

ISSN

0304-3835

Publisher

Elsevier

Peer Reviewed

Yes

Open Access

No

Acceptance Date

11/01/2017

Era Eligible

Yes

Journal

Cancer Letters