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Characteristics of the immunological response in the clearance of non-typeable Haemophilus influenzae from the lung

journal contribution
posted on 06.12.2017, 00:00 authored by A Foxwell, Jennelle KydJennelle Kyd, A Cripps
Clearance of non-typeable Haemophilus influenzae (NTHi) from the respiratory tract was investigated, over time, in immune and non-immune rats. A triphasic pattern characterized the clearance of bacteria from the lungs. Mucosal immunization enhanced bacterial clearance from the lungs in each of the three phases compared with clearance from non-immunized animals. Total clearance of bacteria was observed from lung tissue by 12h in immune animals and 24h in non-immune animals (peaking at 8h post-challenge), compared with non-immune animals (peaking at 12h post-challenge). Systematically derived and locally produced NTHi-specific IgA and IgG correlated with enhanced bacterial clearance during the secondary phase. This model demonstrates that immunized animals up-regulate and resolve inflammatory responses to pulmonary infection more rapidly than the non-immunized controls.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

76

Start Page

323

End Page

331

Number of Pages

9

eISSN

1440-1711

ISSN

0818-9641

Location

United Kingdom

Publisher

Nature Publishing Group

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

University of Canberra; University of Canberra;

Era Eligible

No

Journal

Immunology and cell biology.