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Caulerpa lentillifera (sea grapes) improves cardiovascular and metabolic health of rats with diet-induced metabolic syndrome

journal contribution
posted on 2021-03-31, 01:19 authored by Ryan du PreezRyan du Preez, Marwan E Majzoub, Torsten Thomas, Sunil K Panchal, Lindsay Brown
Caulerpa lentillifera (sea grapes) is widely consumed in South-East Asia as a low-energy food with high contents of vitamins and minerals. This study investigated dried sea grapes containing 16.6% insoluble fibre commercially produced in Vietnam as an intervention. We hypothesised that insoluble fibre is the primary metabolite that will reverse diet-induced metabolic syndrome. Male Wistar rats (n = 48) were randomly allocated to four groups in a 16 week protocol. Two groups were fed either corn starch (C) or high-carbohydrate, high-fat (H) diets for the full 16 weeks. The other two groups received C and H diets for eight weeks and then received C. lentillifera added to these diets for the final eight weeks (CCL and HCL, respectively). High-carbohydrate, high-fat diet-fed rats developed obesity, hypertension, dyslipidaemia, fatty liver disease and increased left ventricular collagen deposition. C. lentillifera supplementation in HCL rats decreased body weight, systolic blood pressure, plasma concentrations of total cholesterol and non-esterified fatty acids, inflammatory cells in heart and liver, and visceral adiposity. The Firmicutes to Bacteroidetes ratio decreased in the gut microbiota of HCL rats. Therefore, C. lentillifera attenuated cardiovascular and metabolic symptoms of metabolic syndrome in rats, possibly by preventing infiltration of inflammatory cells together with modulating gut microbiota.

Funding

Category 3 - Industry and Other Research Income

History

Volume

10

Issue

12

Start Page

1

End Page

18

Number of Pages

18

eISSN

2218-1989

ISSN

2218-1989

Location

Switzerland

Publisher

MDPI

Publisher License

CC BY

Additional Rights

CC BY 4.0

Language

eng

Peer Reviewed

  • Yes

Open Access

  • Yes

Acceptance Date

2020-12-03

External Author Affiliations

University of New South Wales; University of Southern Queensland

Era Eligible

  • Yes

Medium

Electronic

Journal

Metabolites

Article Number

500

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