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COVID-19 therapy: could a copper derivative of chlorophyll a be used to treat lymphopenia associated with severe symptoms of SARS-CoV-2 infection?

journal contribution
posted on 14.07.2021, 00:29 by Nicole F Clark, Andrew Taylor-RobinsonAndrew Taylor-Robinson
Therapeutic doses of SCC have been demonstrated to provide an effective clinical treatment for leukopenia. On this basis, we propose that taking SCC at the onset of symptoms or, for immunocompromised patients, at the time of diagnosis, could reverse the lymphopenia observed during COVID-19. It is envisaged that in symptomatic individuals SCC treatment could control leukocyte homeostasis, specifically of lymphocytes, thereby preventing their progressive reduction that is associated with severe disease outcomes. By first restoring and then maintaining adequate peripheral blood levels of CD4+ and CD8+ T lymphocytes this would enable the immune system of an SCC-treated COVID-19 patient to respond appropriately to resolve SARS-CoV-2 infection. Additionally, it may produce a synergistic effect as SCC is known to block expression of the pro-inflammatory cytokine IL-6. Hence, importantly, such SCC therapy would avoid triggering the characteristically excessive inflammation that causes lasting lung epithelial cell damage and cytokine storm events which often precipitate a fatal outcome of COVID-19.

History

Volume

8

Start Page

1

End Page

5

Number of Pages

5

eISSN

2296-858X

ISSN

2296-858X

Location

Switzerland

Publisher

Frontiers Media

Publisher License

CC BY

Additional Rights

CC BY 4.0

Language

eng

Peer Reviewed

Yes

Open Access

Yes

Acceptance Date

22/02/2021

External Author Affiliations

University of Canberra; Flinders University

Era Eligible

Yes

Medium

Electronic-eCollection

Journal

Frontiers in Medicine

Article Number

620175