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Blackcurrant cultivar polyphenolic extracts suppress CCL26 secretion from alveolar epithelial cells

journal contribution
posted on 31.01.2020, 00:00 by Tafadzwa Nyanhanda, EM Gould, T McGhie, OM Shaw, JL Harper, RD Hurst
Eosinophil recruitment to the airways is a characteristic feature of allergic asthma. Eotaxins are potent chemokines that regulate the recruitment of eosinophils to sites of inflammation. Of these, CCL26 is linked to persistent eosinophil recruitment in the later phase of an allergic response. We evaluated the effectiveness of 10 different blackcurrant cultivar polyphenolic extracts in suppressing CCL26 secretion in stimulated human alveolar epithelial cells. Correlation analysis to identify the potential blackcurrant composition constituent(s) involved in CCL26 suppression and the effects of the four major anthocyanins present in blackcurrants to validate results was conducted. All blackcurrant polyphenolic extracts suppressed CCL26 secretion by lung alveolar cells; however, differential efficacy was observed, which was attributed to their cultivar-specific polyphenolic composition profiles. We identified that the ratio of concentrations of delphinidin glycosides to cyanidin glycosides in the blackcurrant cultivars was an important determinant in influencing CCL26 suppression in lung cells. Our findings support the potential use of blackcurrants or blackcurrant-derived foods/ingredients in managing lung inflammation and the development of specific cultivars as functional foods/ingredients with beneficial biological activities. This journal is © the Partner Organisations 2014.

Funding

Category 3 - Industry and Other Research Income

History

Volume

5

Issue

4

Start Page

671

End Page

677

Number of Pages

7

eISSN

2042-650X

ISSN

2042-6496

Publisher

Royal Society of Chemistry, UK

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

The New Zealand Institute for Plant & Food Research Ltd; Malaghan Institute of Medical Research, NZ

Era Eligible

Yes

Journal

Food and Function

Exports