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Atomic force microscopy on chromosomes, chromatin and DNA: A review

journal contribution
posted on 06.12.2018, 00:00 by W Kalle, Padraig Strappe
The purpose of this review is to discuss the achievements and progress that has been made in the use of atomic force microscopy in DNA related research in the last 25 years. For this review DNA related research is split up in chromosomal-, chromatin- and DNA focused research to achieve a logical flow from large- to smaller structures. The focus of this review is not only on the AFM as imaging tool but also on the AFM as measuring tool using force spectroscopy, as therein lays its greatest advantage and future. The amazing technological and experimental progress that has been made during the last 25 years is too extensive to fully cover in this review but some key developments and experiments have been described to give an overview of the evolution of AFM use from 'imaging tool' to 'measurement tool' on chromosomes, chromatin and DNA. © 2012.

History

Volume

43

Issue

12

Start Page

1224

End Page

1231

Number of Pages

8

eISSN

1878-4291

ISSN

0968-4328

Publisher

Pergamon Press, UK

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Charles Sturt University

Era Eligible

Yes

Journal

Micron

Exports

CQUniversity

Exports