Are exercise programs an effective treatment for children with cystic fibrosis?

Cystic fibrosis (CF) is a genetically inherited, autosomal recessive disease that is caused by a mutation in the gene encoding the cystic fibrosis transmembrane conductance regulator protein. As a result of this deficit, multiple organs, primarily the lungs, pancreas and digestive system, become congested with thick, sticky mucus resulting in infections and inflammation. Despite advances in medical care, life expectancy remains shortened, with 85% of CF‑related deaths caused by lung disease [1]. Exercise capacity in this population may be limited by reduced lung function, nutritional status, metabolic deficits and peripheral muscle function.