Approaches to the use of herbal antiviral compounds against Covid 19 using therapeutic experiences in coronavirus infections of animals

Phytogenic compounds are a valuable and powerful source of effective compounds with diverse biological properties that some of which have good antiviral properties. Modifying the chemical structure of these compounds with computer-based simulations may increase their strength or effectiveness. Due to the great variety of plants, finding an effective plant compound against coronavirus is practically similar to "finding a needle in a haystack". So, considering previous studies on coronaviruses in animals can help in finding of effective plants and phytogenic compounds against SARS-CoV 2. In this study, 28 articles related to anti-coronavirus herbal treatments in animals were selected and analyzed by searching for keywords related to anti-coronavirus herbal treatments in PubMed database. Previous studies have shown that some of the key compounds have shown promising effects in the treatment of coronaviruses including curcumin, hesperidin, artemisinin, silosterol, cineole (eucalyptol), alstotide, lectins such as griffithsin, GNA (Galanthus nivalis agglutinin), lycorine and polyphenolics e.g. quercetin. Before conducting clinical trials in humans, in vitro and in vivo tests are needed to determine the level of immunity, safety, and therapeutic level for each compound. Preliminary studies may focus on compounds that have already been approved for pharmaceutical use or have been identified as safe compound. Researchers may use natural derivatives to produce safe and effective anti-coronavirus agents using the information presented in this review.