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Antifungal diacetyglycerols from Malachra fasciata and Pithecolobium dulce

journal contribution
posted on 06.12.2017, 00:00 by C Ragasa, J Hofilena, A Co, John Rideout
Extracts of Malachra fasciata and Pithecolobium dulce (Roxb.) Benth afforded a mixture of 1,2- and 1,3-diacetylglycerol. Kaempferol-3-0-a-L-rhamnopyranoside, lutein f3-carotene, spinasterol, dodecaprenol, and tridecaprenol were also isolated from P. dulce. The structures of the diacetylglycerols and the glycoside were elucidated by 1D and 2D NMR analyses. The structures of the decaprenols were deduced from mass spectral data, while the other compounds were identified by comparison with the IH NMR data in the literature. The diacetylglycerols indicated high antifungal activity against Aspergillus niger, moderate activity against Pseudomonas aeruginosa and Candida albicans and slight activity against Bacillus subtilis, Escherichia coli, and Trichophyton mentagrophytes. It was inactive against Staphylococcus aureue. Kaempferol-3-0-a-Lrhamnopyranoside was moderately active against the fungus, C. albicans, and has slight activity against the fungi A. niger, T. mentagrophytes, and the bacteria E. coli and P. aeruginosa. It was inactive against the bacteria, S. aureus and B. subtilis.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

19

Issue

1

Start Page

1

End Page

5

Number of Pages

5

ISSN

1020-5586

Location

Malaysia

Publisher

UNESCO

Language

en-aus

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

De La Salle University; Faculty of Arts, Health and Sciences;

Era Eligible

Yes

Journal

ACGC chemical research communications.