File(s) not publicly available

An observational study of the discrediting of COX-2 NSAIDs in Australia : Vioxx or class effect?

journal contribution
posted on 06.12.2017, 00:00 by Lynne ParkinsonLynne Parkinson, X Dolja-Gore, R Gibson, E Doran, L Notley, J Stewart Williams, P Kowal, J Byles
Background: When a medicine such as rofecoxib (Vioxx) is withdrawn, or a whole class of medicines discredited such as the selective COX-2 inhibitors (COX-2s), follow-up of impacts at consumer level can be difficult and costly.The Australian Longitudinal Study on Women’s Health provides a rare opportunity to examine individual consumer medicine use following a major discrediting event, the withdrawal of rofecoxib and issuing of safety warnings onthe COX-2 class of medicines. The overall objective of this paper was to examine the impact of this discrediting event on dispensing of the COX-2 class of medicines, by describing medicine switching behaviours of olderAustralian women using rofecoxib in September 2004; the uptake of other COX-2s; and the characteristics of women who continued using a COX-2.Methods: Participants were concessional beneficiary status women from the Older cohort (born 1921-26) of the Australian Longitudinal Study on Women’s Health who consented to linkage to Pharmaceutical Benefits Schemedata, with at least one rofecoxib prescription dispensed in the 12 months before rofecoxib withdrawal. A prescription was defined as one dispensing occasion. Women were grouped by rofecoxib pattern of use: continuous (nine or more prescriptions dispensed in the 12 months prior to rofecoxib withdrawal) or noncontinuous (eight or less prescriptions dispensed in the 12 months prior to rofecoxib withdrawal) users. Incidence rate per 100,000 person days and incidence risk ratio described uptake of alternate medicines, following rofecoxib withdrawal. Kaplan-Meier curves described differences in uptake patterns by medicine and pattern of rofecoxib use. Patterns of use of COX-2s in the next 100 days after first COX-2 uptake were described. Results: Medicine switches and pattern of medicines uptake differed significantly depending upon whether a woman was a continuous or non-continuous rofecoxib user prior to rofecoxib discrediting. Continuous rofecoxibusers overwhelmingly switched to another COX-2 and remained continuing COX-2 users for at least 100 days postswitch. Conclusions: The typical switching behaviour of this group of women suggests that the issues leading to the discrediting of rofecoxib were not seen as a COX-2 class effect by prescribers to this high use group of consumers.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Volume

11

Issue

892

Start Page

1

End Page

12

Number of Pages

12

eISSN

1471-2458

ISSN

1471-2458

Location

London

Publisher

BioMed Central Ltd.

Language

en-aus

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

TBA Research Institute; University of Newcastle;

Era Eligible

Yes

Journal

BMC public health.