Advancements of microalgal upstream technologies: Bioengineering and application aspects in the paradigm of circular bioeconomy

Sustainable energy transition has brought the attention towards microalgae utilization as potential feedstock due to its tremendous capabilities over its predecessors for generating more energy with reduced carbon footprint. However, the commercialization of microalgae feedstock remains debatable due to the various factors and considerations taken into scaling-up the conventional microalgal upstream processes. This review provides a state-of-the-art assessment over the recent developments of available and existing microalgal upstream cultivation systems catered for maximum biomass production. The key growth parameters and main cultivation modes necessary for optimized microalgal growth conditions along with the fundamental aspects were also reviewed and evaluated comprehensively. In addition, the advancements and strategies towards potential scale-up of the microalgal cultivation technologies were highlighted to provide insights for further development into the upstream processes aimed at sustainable circular bioeconomy.