CQUniversity
Browse

Adenoviral-mediated Interleukin-15 Receptor-α gene therapy of murine breast cancer

journal contribution
posted on 2018-12-07, 00:00 authored by BJ Morrison, Y Tagaya, Jason SteelJason Steel, P Mannan, TA Waldmann, JC Morris, Y Sakai
Interleukin-15 (IL-15) is a critical cytokine involved in the activation, proliferation and survival of natural killer (NK) and CD8+ T cells. The high-affinity IL-15 receptor (IL-15Rα) expressed on monocytes and dendritric cells supplies IL-15 in trans to NK and T cells. Tumor cells engineered to express IL-15Rα may enhance the immune response to tumor. We studied the antitumor activity of adenoviral-mediated transfer of the murine IL-15Rα gene in a mouse breast cancer model.

Funding

Other

History

Volume

13

Issue

S1

Start Page

S165

End Page

S165

Number of Pages

1

ISSN

1525-0016

Publisher

Elsevier (Cell Press)

Full Text URL

Peer Reviewed

  • Yes

Open Access

  • Yes

External Author Affiliations

National Cancer Institute, Bethesda, MD; Kanazawa University Graduate School of Medical Science, Kanazawa, Japan

Era Eligible

  • No

Journal

Molecular Therapy

Usage metrics

    CQUniversity

    Categories

    Keywords

    Interleukin-15CytokineTumorAdenoviral-mediated transferMurine breast cancerCancer Therapy (excl. Chemotherapy and Radiation Therapy)

    Licence

    CQUniversity Open Access 1.0

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC