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Abundance of probiotics and butyrate-production microbiome manages constipation via short-chain fatty acids production and hormones secretion

journal contribution
posted on 04.03.2020, 00:00 by M Zhuang, W Shang, Q Ma, Padraig Strappe, Z Zhou
Scope: The characteristics of gut microbiota and host metabolism are hypothesized to be associated with constipation status, but the regulation mechanism is not fully understood. Thus, the current study investigates the effect of constipation symptoms on gut functionality following the modulation of gut microbiota and metabolites via dietary fiber intervention. Methods and results: Constipation causes a significantly reduced short-chain fatty acids (SCFAs) production and a higher level of iso-butyrate. The feces of constipated people are characterized with inhibited Faecalibacterium, Ruminococcaceae and Roseburia abundance. Desulfovibrionaceae is identified to be an important endotoxin producer in constipated patients, and a butyrate-enriched SCFAs profile achieved by dietary fiber supplement accelerates gastrointestinal transit and increases the thickness of the mucosal layer, possibly through triggering the secretion of colonic hormones and enhancing the expression of tight junction proteins for maintaining intestinal barrier integrity. More importantly, an interacting regulatory mechanism among SCFAs, in particular butyrate and propionate, may be involved in signaling between the microbiome and host cells in the colon. Conclusion: Gut microbiota, characterized with enriched butyrate-producing and depressed Desulfovibrionaceae bacteria, attenuates constipation symptoms through promoting intestinal hormones secretion and maintaining gut barrier integrity. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

Funding

Other

History

Volume

63

Issue

23

Start Page

1

End Page

13

Number of Pages

13

eISSN

1613-4133

ISSN

1613-4125

Publisher

Wiley, Germany

Peer Reviewed

Yes

Open Access

No

External Author Affiliations

Tianjin University of Science and Technology, China; Charles Sturt University

Era Eligible

Yes

Journal

Molecular Nutrition and Food Research