A template-based approach to inhibitors of calpain 2, 20S proteasome, and HIV-1 protease

Specificity counts: A template-based approach to protease inhibitors is presented using a core macrocycle that presents a generic β-strand template for binding to protease active sites. This is then specifically functionalized at P 2 , and the C and N termini to give inhibitors of calpain 2, 20S proteasome, and HIV-1 protease. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.