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A systematic review of Calendula officinalis extract for wound healing

journal contribution
posted on 10.11.2021, 03:38 by Or Givol, Rachel Kornhaber, Denis Visentin, Michelle ClearyMichelle Cleary, Josef Haik, Moti Harats
Use of complementary and alternative medicine for wound healing is influencing mainstream medical practice. This systematic review evaluates the role of Calendula officinalis flower extract as monotherapy compared to control for wound healing in vivo. Searches were conducted in PubMed, EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, and Scopus (up to April 2018) with 14 studies meeting the inclusion criteria, comprising 7 animal experiments and 7 clinical trials. Findings from the review on acute wound healing showed faster resolution of the inflammation phase with increased production of granulation tissue in the test groups treated with extract. These findings were consistent in five animal studies and one randomized clinical trial. Chronic wound healing studies were varied. Two clinical control studies on venous ulcers demonstrated decreased ulcer surface area compared to controls. Another randomized clinical trial demonstrated no improvement for the calendula group in diabetic leg ulcer healing. Burn healing similarly showed mixed results. Two animal studies demonstrated a prophylactic effect for the administration of calendula extract prior to burn injury. A randomized clinical trial of patients suffering from partial to full thickness burns demonstrated no benefit for topical application of calendula extract compared to controls. Two randomized clinical trials assessed the potential for extract to prevent acute post radiation dermatitis, with one study showing improvements compared to trolamine, while the other found no improvement compared to aqua gel cream. Animal studies provide moderate evidence for improved recovery from the inflammation phase and increased production of granulation tissue in calendula extract treatment groups. This review identified some evidence for the beneficial effects of C. officinalis extract for wound healing, consistent with its role in traditional medicine. There is a need for larger, well-designed randomized control trials to assess the effect of calendula on wound healing including complications.

History

Volume

27

Issue

5

Start Page

548

End Page

561

Number of Pages

14

eISSN

1524-475X

ISSN

1067-1927

Location

United States

Publisher

Wiley

Language

eng

Peer Reviewed

Yes

Open Access

Yes

Acceptance Date

20/05/2019

External Author Affiliations

University of Tasmania; Sheba Medical Center, Tel Aviv University, Israel;

Era Eligible

Yes

Medium

Print-Electronic

Journal

Wound Repair and Regeneration