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A cancer stem cell vaccine engineered to express Interleukin-15 and its receptor induces T cell proliferation

journal contribution
posted on 05.12.2018, 00:00 by DK Toukam, Jason SteelJason Steel, C Carwell, I Eldessouki, JC Morris
Introduction. Interleukin-15 (IL-15), a member of the 4-α-helix bundle family of cytokines is a powerful activator and inducer of maturation of both NK and CD8+ cytolytic T cells. It also activates and expands CD8+ T memory cell populations without stimulating immunosuppressive CD4+CD25+ T-regulatory cells. This suggests that IL-15 may be useful as an immunotherapy for the treatment of cancer. In a phase I clinical trial, infusions of recombinant human IL-15 achieved tumor regressions; however, treatment was associated with a systemic inflammatory response syndrome.† In an effort to enhance antitumor activity and reduce systemic side effects, we studied an approach using a vaccine enriched for cancer stem cells (CSCs) genetically altered to express murine (m) IL-15 and its receptor (mIL-15Ralpha).

Funding

Other

History

Volume

25

Issue

5 S1

Start Page

158

End Page

158

Number of Pages

1

ISSN

1525-0016

Publisher

Elsevier (Cell Press)

Additional Rights

Open Archive - Free access to archived material

Peer Reviewed

Yes

Open Access

Yes

External Author Affiliations

University of Cincinnati

Era Eligible

No

Journal

Molecular Therapy