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Motion tracking of fully conscious small animals in PET

conference contribution
posted on 2017-12-06, 00:00 authored by A Kyme, Weidong Zhou, S Meikle, K Popovic, W Man, M Akhtar, I Karllsson, R Fulton
Pre-clinical positron emission tomography (PET) is becoming increasingly important in understanding brain physiology using animal models. One of the major challenges at present is being able to perform brain PET studies without the use of anesthesia. In most cases where the animal is minimally restrained this will require someform of motion tracking to provide the necessary temporal pose information for compensation before or during image reconstruction (eg. [1, 2]). In previous work we have demonstrated successful tracking of continuous movement in phantom studies and an anesthetized rat study in which the animal was moved manually [2]. Here we report on our first trials tracking the head of fully conscious rats moving continuously during emission and transmission PET acquisitions performed on a microPET Focus 220 scanner (SiemensPreclinical Solutions, Knoxville, USA). The motion tracking is based on a commercial stereo-optical motion tracking device called the MicronTracker Sx60 (Claron Tech. Inc., Toronto, Canada). We have previously reported in detail on this device and its suitability forsmall-scale motion tracking [3]. In this paper we (i) describe the motion tracking setup and marker considerations used for conscious animal head tracking, (ii) describe our animal handling methods,(iii) present data on motion tracker performance in the conscious animal trials, (iv) present data and observations on the character of rat movements in the imaging environment, and (v) show examples of the correction that can be obtained using these data for motion compensation.

Funding

Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)

History

Start Page

2561

End Page

2566

Number of Pages

6

Start Date

2009-01-01

ISSN

1082-3654

ISBN-13

9781424439621

Location

Orlando, Florida, USA

Publisher

IEEE Operations Center

Place of Publication

Piscataway, NJ

Peer Reviewed

  • Yes

Open Access

  • No

External Author Affiliations

Not affiliated to a Research Institute; University of Sydney; Westmead Hospital;

Era Eligible

  • Yes

Name of Conference

Nuclear Science Symposium