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A method for single trait quantitative trait loci estimation in F₂ crosses between outbred lines
conference contribution
posted on 2017-12-06, 00:00 authored by JW Daley, Ross ShepherdRoss Shepherd, J HenshallA new approach for Quantitative Trait Loci (QTL) analysis in designed experiments is investigated using a mixed model framework through the modification of segment mapping techniques. Allele effects are modelled in the F1 generation allowing the estimation of additive substitution effects while accounting for QTL segregation within lines as well as differences in mean QTL effects between lines. The resulting approach is called F1 origin mapping where additive genetic variances are estimated via Restricted Maximum Likelihood (REML) and allele effects are modelled using Best Linear Unbiased Prediction (BLUP). By coupling this new approach with the computer program ASREML, F1 origin mapping provides a flexible and efficient tool for QTL studies. A simple genetic simulation study is presented to illustrate the method and its properties.
Funding
Category 1 - Australian Competitive Grants (this includes ARC, NHMRC)
History
Start Page
1End Page
4Number of Pages
4Start Date
2003-01-01Finish Date
2003-01-01ISBN-10
0958629927Location
Melbourne, AustraliaPublisher
Association for the Advancement of Animal Breeding and GeneticsPlace of Publication
Armidale, N.S.W.Peer Reviewed
- Yes
Open Access
- No
External Author Affiliations
CSIRO Livestock Industries; Conference; Faculty of Informatics and Communication; TBA Research Institute;Era Eligible
- Yes