Rural occupational therapy service provision has distinctive characteristics that present a multitude of rewarding opportunities, as well as some professional and personal challenges. The unique issues faced by occupational therapists practising in regional, rural and remote areas of Australia have been the subject of investigation for some time (Devine 2006; Burke et al. 2012; Merritt et al. 2013). Researchers have identified factors such as: the responsibilities of carrying a large and varied caseload as a sole therapist, travelling large distances in remote locations, perceptions of geographic and professional isolation, reduced access to continuing professional development, concerns about future career paths and opportunities, variations in health systems and local health services and social complexities of living and working among regional communities, all impacting on the power of the therapist to make a difference. While these characteristics could be seen as challenges, it is possible to have a rewarding and fulfilling rural occupational therapy career if therapists have an awareness of these factors and develop strategies to manage them. This chapter aims to i) describe the context for regional, rural and remote practice; ii) summarise some of the characteristics of regional, rural and remote practice; and iii) highlight strategies to manage challenges and accentuate the positives of regional, rural and remote practice.